Blar i NTNU Open på forfatter "Lindholm, Håvard Takle"
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BMP signaling in the intestinal epithelium drives a critical feedback loop to restrain IL-13-driven tuft cell hyperplasia
Lindholm, Håvard Takle; Parmar, Naveen; Drurey, Claire; Poveda, Marta Campillo; Vornewald, Pia; Ostrop, Jenny; Sanchez, Alberto Diez; Maizels M, Rick; Oudhoff, Menno (Peer reviewed; Journal article, 2022)Intestinal parasite infections or allergic reactions promote IL-13–induced differentiation of tuft cells as one manifestation of type 2 immunity in the gut. Using organoid cultures of intestinal epithelial cells, Lindholm ... -
Characterisation of Colorectal Cancer Cell Lines through Proteomic Profiling of Their Extracellular Vesicles
Heck, Kathleen; Lindholm, Håvard Takle; Niederdorfer, Barbara; Tsirvouli, Eirini; Kuiper, Martin; Flobak, Åsmund; Lægreid, Astrid Renner; Thommesen, Liv (Journal article; Peer reviewed, 2023) -
Defining changes in the intestinal epithelium in early life and in response to infections
Lindholm, Håvard Takle (Doctoral theses at NTNU;2021:231, Doctoral thesis, 2021) -
Differentially expressed extracellular vesicle-contained micrornas before and after transurethral resection of bladder tumors
Strømme, Olaf; Heck, Kathleen; Brede, Gaute; Lindholm, Håvard Takle; Otterlei, Marit; Arum, Carl-Jørgen (Peer reviewed; Journal article, 2021)Bladder cancer (BC) is currently diagnosed and monitored by cystoscopy, a costly and invasive procedure. Potential biomarkers in urine, blood, and, more recently, extracellular vesicles (EVs), have been explored as ... -
LSD1 represses a neonatal/reparative gene program in adult intestinal epithelium
Zwiggelaar, Rosalie; Lindholm, Håvard Takle; Fosslie, Madeleine Lystad; Pedersen, Marianne Terndrup; Ohta, Yuki; Díez-Sánchez, Alberto; Martín-Alonso, Mara; Ostrop, Jenny; Matono, Mami; Parmar, Naveen; Kvaløy, Emilie; Spanjers, Roos; Nazmi, Kamran; Rye, Morten Beck; Drabløs, Finn; Arrowsmith, Cheryl H; Dahl, John Arne; Jensen, Kim B.; Sato, Toshiro; Oudhoff, Menno (Journal article; Peer reviewed, 2020)Intestinal epithelial homeostasis is maintained by adult intestinal stem cells, which, alongside Paneth cells, appear after birth in the neonatal period. We aimed to identify regulators of neonatal intestinal epithelial ... -
Mmp17- deficient mice exhibit heightened goblet cell effector expression in the colon and increased resistance to chronic Trichuris muris infection
Vornewald, Pia Magdalena; Forman, Ruth; Yao, Rouan; Parmar, Naveen; Lindholm, Håvard Takle; Lee, Lilith Sian Kaspersen; Martin Alonso, Mara; Else, Kathryn J.; Oudhoff, Menno Johannes (Peer reviewed; Journal article, 2023)Intestinal epithelial homeostasis is maintained by intrinsic and extrinsic signals. The extrinsic signals include those provided by mesenchymal cell populations that surround intestinal crypts and is further facilitated ... -
Smooth muscle-specific MMP17 (MT4-MMP) regulates the intestinal stem cell niche and regeneration after damage
Alonso, Mara Martin; Iqbal, Sharif; Vornewald, Pia; Lindholm, Håvard Takle; Damen, Mirjam J.; Martínez, Fernando; Hoel, Sigrid; Sanchez, Alberto Diez; Altelaar, Maarten; Katajisto, Pekka; Arroyo, Alicia G.; Oudhoff, Menno (Peer reviewed; Journal article, 2021)Smooth muscle is an essential component of the intestine, both to maintain its structure and produce peristaltic and segmentation movements. However, very little is known about other putative roles that smooth muscle cells ...